Carrying pillars help
overcome hindrances. We have them.
Electronic Medical Record
The central pillar is the so called electronic medical record, in which all data are collected in a patient-centered manner. This setup allows CentraXX -contrary from conventional systems that are used for billing and sample administration purposes- to finally truly meet medical-epidemiological demands, and it allows for a longitudinal view. Single and isolated snapshots, which can only partially uncover connections and long-term factors, will soon belong to the past.
A further important building block is unified documentation, which is achieved through a form processor. This enables a proactive and structured documentation of all relevant aspects. The form processor integrated in the CentraXX-Meta-Module works with reusable components that help to avoid mountains of paperwork. It also reduces the amount of errors during transmission. Additionally, information which has already been entered can be combined with contextually relevant data from questionnaires/forms. This type of documentation has the advantage of making ad-hoc orders possible, since the system can make the user aware of conditions that match with system-defined SOPs. As a helpful side-effect, one can achieve a situation in which filling out order forms for standard procedures in research becomes obsolete.
Workflow-Engine A workflow engine is a software application, which defines a process, follows established rules for said process, and executes it accordingly.
The central controlling instrument of CentraXX is the so called Workflow-Engine, which allows for an efficient implementation of the heterogeneous demands of research. The use of the workflow engine allows CentraXX to remain flexible and usable for studies with various characteristics, regardless if they are clinical, population-based, or related to treatment. Available components or process chains can be reused accordingly. This makes it possible for CentraXX to execute defined paths for the study order, the sample documentation, the information collection, and for analysis. Consequently, CentraXX can make all relevant results available for local sites, as well as for participating partner sites. Thus, the IT/platform follows the research approach of personalized Medicine, which requires the exact control of therapy procedures in both a logical and chronological order. Once processes have been established within a project, they can be implemented and executed on the platform.
CentraXX has the task of gathering patient relevant information in the context of research, according to specific rules, and then disseminating this information to those involved in the research.
The integrated workflow engine allows for an orchestration of processes, as well as patient centered documentation according to SOPs and further quality standards that must be defined.
CentraXX orchestrates the partner’s work process through activity lists. This makes the parallelization of processes in the field of in vivo, in vitro, and in silico possible, which momentarily are only run in sequences at some sites. Such parallelization can result in enormous time savings. The processes can be divided into main processes and partial processes, as known from Business Process Management. This makes it possible to reuse frequently recurring partial processes for other main processes.
Furthermore, service level agreements for the cooperating institutions can be defined (who provides what in which quality and time?). CentraXX and its workflow engine model these agreements and execute them in a rule-based manner.
The system automatically informs those responsible about violations of agreements, so that adjustments can be made immediately. This creates a higher level of trust between all actors, and enables the continuation of time critical processes in a quality secured manner which shortens the long waiting times needed for coordinative communication via mail or phone.
Additionally, CentraXX Meta offers backend functionalities such as a Data Dictionary, Meta Data Repository, and an Evaluation Engine. Using the Data Dictionary and Meta Data Repository can guarantee a coordinated growth of attributes and forms. This will ensure that all researchers can use their own vocabulary, and have all words mapped to one and the same term in the system. The expansion of this vocabulary set is controlled by administrators, which allows the customers to make changes on their own. A term, once defined, can be reused for all evaluations and in other forms.
The Reporting- and Statistics Module is an integrated part of CentraXX Meta.
There are searches, reports (automatic or self-generated) and statistics in CentraXX Meta. In general, all data points of the Data Dictionary are searchable. All data fields that have been entered can be included in a search. Combining search parameters is possible, as is a cascading search. Result sets from any specific time can be saved and exported.
Reports are generated with the BIRT Engine Business Intelligence and Reporting Tools (BIRT) is an open source project that offers reporting and business intelligence functionalities, and has been integrated into CentraXX , which makes comprehensive SQL-queries possible. One can for example generate lists of studies as well as their annual recruiting numbers sorted by entities. Reports covering general aspects in a biobank, such as sample inventory lists can also be used. In addition, reports for the comparison between treatment methods and goal descriptions can be offered. Reports can be modelled individually and can be defined by the customers themselves after a short training offered in workshops. They can be saved as Excel or PDF files at any time, and are exportable.
One of the most important tasks of a research platform such as CentraXX, is the handling of sensitive data. Common available guidelines, be it by the ZTG or the TMF e.V., provide some strategies. A specific concept, which the operator of a research platform may favor, is often not described in detail in those guidelines however. For obvious reasons, models by the TMF and the ZTG are often combined. This does not create any roadblocks for CentraXX, which can support all models.
In general, all crucial mechanisms for ID-Management can be used in CentraXX, which can account for and manage as many IDs for patients and samples as needed. This is an important basis for the communication with other ID-based systems. Communication with external trust agencies is also of great importance. In the Nationale Kohorte project, the Institute of Greifswald and Kairos are working together on a close interaction between the implemented trust agency and CentraXX. The DKTK project had implemented an ID management developed by the IMBEI Mainz. This ID management had to be integrated into CentraXX within that project. If no external ID management is required, CentraXX can also offer its own internal pseudonymization algorithms.